Seladelpar Found Safe and Effective For Patients With PBC and Cirrhosis

The newly approved drug seladelpar was found to be safe and effective in treating patients with both PBC and ...

MAY 15, 2025

Evolving the Treatment Paradigm in Second-Line Primary Biliary Cholangitis With IQIRVO (elafibranor): A First-in-Class PPAR Agonist

This Special Report discusses considerations for monitoring and treating patients with primary biliary cholangitis ...

APRIL 1, 2025

FDA Issues Serious Liver Injury Warning for Obeticholic Acid

The FDA has issued a warning of serious liver injury for patients taking obeticholic acid for primary biliary ...

DECEMBER 16, 2024

FDA Declines to Grant Full Approval to Obeticholic Acid for PBC

The FDA has declined to grant full approval to obeticholic acid (Ocaliva, Intercept) for the treatment of adults ...

NOVEMBER 14, 2024

FDA Approves Seladelpar for Primary Biliary Cholangitis

The FDA has granted accelerated approval to seladelpar (Livdelzi, Gilead) in combination with ursodeoxycholic acid ...

AUGUST 21, 2024

FDA Approves Elafibranor for Primary Biliary Cholangitis

The FDA granted accelerated approval for elafibranor (Iqirvo, Ipsen), a peroxisome proliferator−activated ...

JUNE 12, 2024

7 Steps to Manage Pruritus in Liver Disease

It’s not just patients with primary biliary cholangitis. Patients with liver disease of all different ...

MAY 23, 2024

Easing ALP Cutoffs Could Allow More With PBC to Benefit From New Therapies

Patients with primary biliary cholangitis who have low alkaline phosphatase levels may need second-line therapy, ...

DECEMBER 16, 2023

Expert Picks From The Liver Meeting, Part 2

In this second installment of “Expert Picks” from The Liver Meeting 2022, Ashwani K. Singal, MD, MS, ...

APRIL 19, 2023

Obeticholic Acid Proves Its Mettle As Second-Line Therapy for PBC

Patients with primary biliary cholangitis treated with obeticholic acid as second-line therapy within the POISE ...

NOVEMBER 29, 2022

Promising New Second-Line Therapy for Primary Biliary Cholangitis Emerges, More Data to Come

Seladelpar could eventually become the standard second-line treatment for primary biliary cholangitis, according to ...

MARCH 9, 2021

Pipeline Rich for Bile Acid Drugs

Arlington, Va.—Hepatologists treating patients with cholangiopathies have had few options. But that might be ...

OCTOBER 3, 2018