First-degree relatives of people with metabolic dysfunction–associated steatotic liver disease are at higher risk for developing hepatocellular carcinoma, according to a longitudinal study. This is especially true if those with MASLD have advanced fibrosis or cirrhosis.
“There was this notion that [MASLD] has a high degree of heritability and, therefore, first-degree relatives were at greater risk, but no long-term study had been performed,” said investigator Fahim Ebrahimi,