Despite its low incidence, pancreatic ductal adenocarcinoma remains the fourth leading cause of cancer-related deaths in the world, mainly due to dismal rates of survival.
Even after surgical resection, one-year survival is achieved in less than 20% of cases and five-year survival rate is only 5% to 7% (Lancet 2011;378[9791]:607-620). At the 2019 Society of Surgical Oncology (SSO) Annual Cancer Symposium, Matthew H.G. Katz, MD, outlined the limitations of surgery in the setting of locally