In a group of people diagnosed with colorectal cancer before 50 years of age, post-resection surveillance according to recommended intervals failed to detect more than half the metachronous high-risk lesions that developed, researchers in Texas have found.
Patients with sporadic young-onset CRC are thought to have a more biologically active colorectum that is prone to malignant transformation earlier in life. Whether their risk for metachronous colorectal pathology after the index cancer also is