Twenty-nine U.S. cases of resistant typhoid fever were identified in people who had traveled to or from Pakistan between 2016 and 2018. Of these, five were confirmed to have the extensively drug-resistant (XDR) strain (MMWR Morb Mortal Wkly Rep 2019;68[1]:11-13).
From 2016 to 2018, more than 5,000 cases of drug-resistant typhoid fever were reported in Pakistan. The diagnosed infections illustrate the increasing risk of travel in spreading antimicrobial-resistant infections, according to the CDC.