DECEMBER 27, 2023

The Incretin Effect

Ion A. Hobai, MD, PhD
Anesthesiologist
Massachusetts General Hospital Assistant Professor of Anesthesia
Harvard Medical School Boston

I remember the discovery of glucagon-like peptide-1 (GLP-1) sometime in the late 1980s. It came as the answer to a finding so strange, so blatantly dissonant, that even a junior medical student like myself, who was devouring science journals at the American Library in Bucharest, Romania, was finding it deeply disturbing: During glucose tolerance tests, the same