Top-Down or Step-up Treatment For Newly Diagnosed CD, Standard or Intensified Infliximab Induction for ASUC

Miguel Regueiro, MD

Professor of Medicine
Chief of the Digestive Disease Institute
Cleveland Clinic, Cleveland

This month’s report examines two key studies on treatments for inflammatory bowel disease. They provide clarity about treatment strategies for people with newly diagnosed Crohn’s disease and those with steroid-refractory acute severe ulcerative colitis (ASUC).

The PROFILE study compared top-down and accelerated step-up treatment approaches for newly diagnosed CD. The top-down