
The FDA has issued an alert to healthcare professionals regarding the rare but significant risk for intrahepatic cholestasis of pregnancy linked to the use of thiopurines, including 6-mercaptopurine, 6-thioguanine and azathioprine.
Thiopurines, which carry an established risk for hepatotoxicity, already come with warnings about the potential for causing fetal harm when used during pregnancy, but in light of the newly identified risk for ICP, the FDA strongly advises that pregnant patients