Esophageal and Swallowing Center
Division of Gastroenterology and Hepatology
MetroHealth Medical Center
Case Western Reserve University
Cleveland, Ohio
The Rome IV criteria, published in 2016, introduced 2 functional esophageal disorders that have heartburn as their predominant symptom: functional heartburn (FH) and reflux hypersensitivity. 1
The main effect of Rome IV on functional esophageal disorders was the recognition that reflux hypersensitivity,