San Francisco—Proton pump inhibitors might affect the absorption and therefore the effectiveness of capecitabine, a drug commonly used in the adjuvant treatment of colorectal cancer, new research indicates.
First-line adjuvant chemotherapy options for stage 2 to 3 colorectal cancer include XELOX (capecitabine, oxaliplatin) and FOLFOX (oxaliplatin, leucovorin and 5-fluorouracil). Capecitabine is an oral 5-fluorouracil prodrug that is administered in an inactive form and activated by normal